Our Live Biotherapeutics are dedicated to unlocking the therapeutic value of Christensenella, as well as other microbiome bacteria.
This program is built on first-in-class scientific publications that have identified christensenella as a cornerstone of healthy human intestinal microbiota.
The bacterial strain specifically selected for this program comes from LNC Therapeutics’ proprietary library.
LNC01 showed strong efficacy results in preclinical animal models and is expected to enter clinical development in 2020.
Our approach is supported by compelling epidemiological and clinical data that have demonstrated a strong link between the presence of keystone bacteria and reduced risks of developing inflammatory bowel disorders.
General review of gut microbiome changes in IBD showing consistant association between CD and a loss of Christensenellacea
Pittayanon, R., Lau, J.T., Leontiadis, G.I., Tse, F., Yuan, Y., Surette, M., and Moayyedi, P. (2019). Differences in Gut Microbiota in Patients With vs Without Inflammatory Bowel Diseases: a Systematic Review. Gastroenterology 1–52.
Important paper showing that loss of Christensenella is predictive of CD flare.
Braun, T., Di Segni, A., BenShoshan, M., Neuman, S., Levhar, N., Bubis, M., Picard, O., Sosnovski, K., Efroni, G., Farage Barhom, S., et al. (2019). Individualized Dynamics in the Gut Microbiota Precede Crohnʼs Disease Flares. Am. J. Gastroenterol. 1–10.
Multiple complex mechanisms of action are at play in this relationship, but although there is still a lot to discover, there is strong support for an action of the gut microbiome on neuroinflammation. LNC Therapeutics is therefore initiating research in this exciting area to harness the potential of carefully selected bacteria strains to treat behavioural diseases that are linked to gut dysbiosis.
Pr. John Cryan, a neuropharmacologist and microbiome expert from the University College Cork, shares surprising facts and insights about how our thoughts and emotions are connected to our gut.
Discover John Cryan on TEDMED