Publications

Human Genetics Shape the Gut Microbiome

Jan 2, 2019

 

Julia K. Goodrich, et al.

 

Host genetics and the gut microbiome can both influence metabolic phenotypes. However, whether host genetic variation shapes the gut microbiome and interacts with it to affect host phenotype is unclear. Here, we compared microbiotas across >1,000 fecal samples obtained from the TwinsUK population, including 416 twin pairs. We identified many microbial taxa whose abundances were influenced by host genetics. The most heritable taxon, the family Christensenellaceae, formed a co-occurrence network with other heritable Bacteria and with methanogenic Archaea. Furthermore, Christensenellaceae and its partners were enriched in individuals with low body mass index (BMI). An obese-associated microbiome was amended with Christensenella minuta, a cultured member of the Christensenellaceae, and transplanted to germ-free mice. C. minuta amendment reduced weight gain and altered the microbiome of recipient mice. Our findings indicate that host genetics influence the composition of the human gut microbiome and can do so in ways that impact host metabolism.

 

Full article

In the same category

Publications

Christensenella as an emerging target to attain longevity

Jan 11, 2019

more +
Publications

Gut Microbes and Health: A Focus on the Mechanisms Linking Microbes, Obesity, and Related Disorders

Jan 2, 2019

more +
Publications

Milk-derived bioactive peptides and obesity

Jan 2, 2019

more +

LNC Therapeutics © 2019 - all rights reserved terms and conditions